Aim: The point of the present investigation planned to assess the nutritive value, minerals content, vitamin content, antinutritional properties, and toxicity studies in five wild-consumable plants, for example, Begonia hatacoa, Embelia floribunda, Artemisia vulgaris, Cardamine hirsuta, and Plantago major, devoured by the distinctive innate individuals of Meghalaya State in India as their nourishment. Materials and Methods: The proximate parameters such as protein, fat, fiber, sugar, minerals, and harmful overwhelming metals were assessed in the chose wild-eatable plants utilizing standard sustenance examination procedures. The cyanogenic glycoside, oxalates, tannins, saponins, and phytate substances were done to decide the counter wholesome properties of the considered plants. The quantitations of water-dissolvable vitamins in these plants were completed by high-performance liquid chromatography. The in vitro hemolytic measure of plant concentrates was completed on rodent erythrocytes. Appraisal of cytotoxicity of eatable plants was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide examine. The genotoxicity of the contemplated plants was tried by the single-cell gel electrophoresis comet assay. Results: The consequences of examination demonstrated that these plants are rich wellsprings of protein, sugar minerals, and vitamins, particularly the B gathering of vitamins. The substantial metals lead and chromium were distinguished in exceptionally low sum in all the consumable plants. The largest amount of phytate was found in P. major (0.38% ± 0.03%); oxalate was most astounding in E. floribunda (0.261% ± 0.06%) though tannin was most elevated in P. major (1.04% ± 0.12%). The estimations of antinutrients and overwhelming metals in all above-considered plants are underneath the harmful levels. Conclusion: These wild-eatable plants contribute gigantically to sustenance, nourishment security, well-being, and remedial advantages. The aftereffects of poisonous quality of every single eatable plant ensure the security at cell and genomic level and furthermore safe to expend.