New Sesquiterpene and Polymethoxy-Flavonoids from Artemisia annua L

Yang Chu; Hongbo Wang; Jing Chen; Yue Hou

Articles

Abstract

Pharmacognosy Magazine,2014,10,39,213-216.

DOI:10.4103/0973-1296.137359

Published:July 2014

Type:Original Article

Authors:

Author(s) affiliations:

Yang Chu¹, Hongbo Wang², Jing Chen³, Yue Hou⁴
¹ Department of Pharmacy, the First Affiliated Hospital of China Medical University, 155 Nanjing Street, Shenyang; Department of the First Clinical Pharmacy, School of Pharmacy, China Medical University, 92 Bei'er Road, Shenyang, China
² Department of Natural Natural Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, China
³ Department of Pharmaceutics, Ningxia Medical University, Yinchuan, China
⁴ College of Life and Health Sciences, Department of Biochemistry and Molecular Biology, Northeastern University, Shenyang, 110819, China

Abstract:

Our previous study revealed that the polymethoxy-flavonoids, as main components of Artemisia annua, could improve the antimalarial activity of Artemisinin. Here, we described the isolation, elucidation, constituent analysis, flavonoids enrichment of the extracts of A. annua. A total of 20 compounds were isolated including a new sesquiterpene (compound 12) and five (1, 5, 6, 7, 15) afforded for the first time from A. annua. The elucidation of eight flavonoids may be a useful phytochemical data and chemical foundation for further mechanism studies on improving the anti-malarial action of artemisinin. Furthermore, the antitumor activities of the compounds were assayed using four different kinds of human cancer cell lines.

Keywords:Antitumor activities, artemisinin, Polymethoxy-flavonoid, sesquiterpene