Dietary supplementation of Hemidesmus indicus and swimming exercise attenuates oxidative stress in the rat brain

Background: In the current investigation, we explored the impact of swimming training and dietary fortification of Hemidesmus indicus (HI) extract on markers of oxidative stress (OS) and antioxidant capacity in the middle-aged Wistar rats. Materials and Methods: Male rats received oral supplementation of HI at a dosage of 50 and 100 mg/kg B.W and swim trained for 30 min/day with 3% intensity, 6 days/week for a duration of 84 days. Results: Training and dietary intake of 100 mg/Kg B.W HI extract enhanced antioxidant enzyme activities in the discrete regions of the brain. The OS indicators were attenuated in response to single or combined interventions. The levels of thiols were significantly upregulated in SW-T (+HI2) group. Conclusion: Our findings suggest that both interventions improve antioxidant status, by attenuating the OS markers, which can be used as a therapeutic strategy in preventing age-associated neurological disorders.