Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway

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Abstract
Pharmacognosy Magazine,2015,11,42,404-409.
Published:March 2015
Type:Original Article
Authors:
Author(s) affiliations:

Xiang-An Zhang1, Shuangxi Zhang1, Qing Yin2, Jing Zhang1
1 Anorectal Disease Center, The First Affiliated Hospital, Henan College of TCM, Zhengzhou 450000, China
2 Department of Hematological Malignancy, The Affiliated Hospital, Henan TCM Research Academy, Zhengzhou 450000, China

Abstract:

Quercetin can inhibit the growth of cancer cells with the ability to act as chemopreventers. Its cancer-preventive effect has been attributed to various mechanisms, including the induction of cell-cycle arrest and/or apoptosis as well as the antioxidant functions. Nuclear factor kappa-B (NF-κB) is a signaling pathway that controls transcriptional activation of genes important for tight regulation of many cellular processes and is aberrantly expressed in many types of cancer. Inhibitors of NF-κB pathway have shown potential anti-tumor activities. However, it is not fully elucidated in colon cancer. In this study, we demonstrate that quercetin induces apoptosis in human colon cancer CACO-2 and SW-620 cells through inhibiting NF-κB pathway, as well as down-regulation of B-cell lymphoma 2 and up-regulation of Bax, thus providing basis for clinical application of quercetin in colon cancer cases.

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