Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants

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Abstract
Pharmacognosy Magazine,2011,7,26,171-175.
Published:May 2011
Type:Short Communication
Authors:
Author(s) affiliations:

Christine Chichioco-Hernandez1, Jakub Wudarski2, Lieven Gevaert2, Luc Verschaeve3
1Bioorganic and Natural Products Laboratory, Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines
2Gentaur BVBA, Kampenhout, Belgium
3Laboratory of Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium

Abstract:

The genotoxicity and toxicity of ethnomedicinal Philippine plants, which include Cassia fistulaDerris ellipticaFicus elasticaGliciridia sepiumMichelia albaMorus albaPogostemon cablin and Ricinus communis, were tested using the Vitotox assay. The plants are used traditionally to treat several disorders like diabetes, weakness, menorrhagia, headache, toothache and rheumatism. The dried leaves were homogenized for overnight soaking in methanol at room temperature. The resulting alcoholic extracts were filtered and concentrated in vacuo and tested for their genotoxicity and cytotoxicity using Vitotox®. Results showed that the medicinal plants that were tested are not genotoxic nor cytotoxic, except for R. communis and P. cablin, which showed toxicity at high doses (low dilutions) in the absence of S9.

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