A pentacyclic triterpenoid possessing anti-inflammatory activity from the fruits of Dregea volubilis

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Abstract
Pharmacognosy Magazine,2009,5,19s,64-68.
Published:July 1, 2009
Type:Research Article
Authors:
Author(s) affiliations:

M Biswas1, K Biswas2, AK Ghosh3, PK Haldar4
1Bengal Institute of Pharmaceutical Sciences, Kalyani, Nadia-741 235, West Bengal, India
2BCDA College of Pharmacy & Technology, Barasat, Kolkata-700 127, West Bengal, India
3Bengal School of Technology, Delhi Road, Sugandha, Dt. Hooghly, PIN: 712 102, West Bengal, India
4Division of Pharmacology, Dept. of Pharmaceutical Technology, Jadavpur University, Kolkata- 700 032, West Bengal, India

Abstract:

The aim of the study is to find anti-inflammatory activity of the compound obtained from the petroleum ether extract of the fruits of Dregea volubilis. Fruits of Dregea volubilis were extracted by petroleum ether and through column chromatography led to obtain a compound. The structure of the compound was determined on the basis of IR, MASS, NMR (PMR, CMR and DEPT) spectroscopic analysis. The compound was screened for anti-inflammatory activity in albino rats using acute carageenan induced paw oedema. The petroleum ether extract of the fruits of Dregea volubilis Benth led to isolation and characterization of a pentacyclic triterpenoid compound designated as taraxerol and characterized as D- friedoolean- 14- en, 3 ol [Figure 1]. It has shown significant anti-inflammatory activity in albino rats. Anti-inflammatory activity in albino rats has been shown by taraxerol obtained from the petroleum ether extract of the fruits of Dregea volubilis.

Keywords:anti-inflammatory activity, Dregea volubilis Benth, pentacyclic triterpenoid, taraxerol

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Keywords
anti-inflammatory activity
Dregea volubilis Benth
pentacyclic triterpenoid
taraxerol