Colocasia esculenta L. schott corm mucilage: A selective COX-2 inhibitor for treatment of irritable bowel syndrome

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Abstract
Pharmacognosy Magazine,2021,17,74,387-390.
Published:July 2021
Type:Original Article
Authors:
Author(s) affiliations:

Nesrin M Fayek1, Samar M Mouneir2, Azza Ramy Abdel Monem1, Samia M Abdelwahab1, Nebal D Eltanbouly1
1 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2 Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt

Abstract:

Background: Therapeutic strategies used for the treatment of irritable bowel syndrome having many limitations due to their side effects; this necessitates searching for new substitutes with similar therapeutic results and limited side effects. In the present study, the anti-inflammatory activity of the mucilage of Colocasia esculenta L. Schott var. typical corm cultivated in Egypt was explored both in vivo and in vitro. Materials and Methods: In vivo anti-inflammatory activity was evaluated based on histopathological examination, determination of ulcer area and ulcer index, and measurement of inflammatory mediators, namely, myeloperoxidase, malondialdehyde, nitric oxide, and tumor necrosis factor-α, in acetic acid-induced ulcerated rat colon, comparing to Prednisolone as a reference drug. In vitro evaluation of the anti-inflammatory activity of the tested mucilage was carried out by measuring its cyclooxygenase (COX-1/COX-2) and 5-lipoxygenase inhibitory activity comparing to Celecoxib and Zileuton as reference drugs, respectively. Results: Pretreatment with the mucilage improved the histopathological features of the rats ulcerated colon and decreased the ulcer area and the ulcer index in a dose-dependent manner. The mucilage improved all the tested inflammatory mediators. In addition, it has a potent COX-2 inhibitory activity with lower effect on COX-1 and 5-lipooxygenase. Conclusion: The obtained results support the use of C. esculenta corm mucilage as an alternative for the treatment of inflammatory bowel disease with minimum gastrointestinal side effects.

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IC50 of the Colocasia esculenta L. Schott corm mucilage on COX- 1, COX-2 and 5-LOX activity in acetic acid-induced rat colitis comparing to reference drugs
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