Immunostimulant activity of Bergenia Extracts

Lenka Tumova; Helena endrychová; Doris Vokurkova

Articles

Abstract

Pharmacognosy Magazine,2018,14,56,328-332.

DOI:10.4103/pm.pm_423_17

Published:August 2018

Type:Original Article

Authors:

Author(s) affiliations:

Lenka Tumova¹, Helena endrychová¹, Doris Vokurková²
¹ Department of Pharmacognosy, Faculty of Pharmacy Hradec Králové, Charles University, Sokolská, Hradec Králové, Czech Republic
² Departmen of Clinical Immunology and Allergology, Faculty of Medicine and University Hospital, Charles University, Sokolská, Hradec Králové, Czech Republic

Abstract:

Background: Bergenia species contain various therapeutically important compounds such as phenolic compounds-arbutin, bergenin, tannins, gallic acid, flavonoids, minerals, and many others. Bergenia plants show antibacterial, antiviral, anticancer, antidiabetic, diuretic and immunostimulant activities. Materials and Methods: Bergenia leaf extracts from Bergenia crassifolia, Bergenia ciliata, and Bergenia x ornata on lymphocyte activation using flow cytometry method were investigated. Their activation was then monitored with the help of the increasing fluorescence intensity. Results: By activating of cells, there has been an increase in the amount of the established antibodies. Bergenia extracts significantly stimulated the expression of CD69 on lymphocytes in the final concentration of 3.13 and 6.25 mg/ml. The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ. Conclusion: The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ.