Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells

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Abstract
Pharmacognosy Magazine,2014,10,38,161-164.
DOI:10.4103/0973-1296.131028
Published:April 2014
Type:Original Article
Authors:
Author(s) affiliations:

Jin Bae Weon1, Bohyoung Lee1, Bo-Ra Yun1, Jiwoo Lee1, Choong Je Ma2
1 Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, Korea
2 Department of Medical Biomaterials Engineering, College of Biomedical Science; Research Institute of Biotechnology, Kangwon National University, Chuncheon, Korea

Abstract:

Background: Cynanchum paniculatum, belongs to the family Asclepiadaceae and is used to treat various diseases, such as invigorate blood, alleviate edema and to relieve pain and toxicity for a long time. Materials and Methods: 4,5-Dimethoxypyrocatechol was isolated from the 80% methanol extract of C. paniculatum and its neuroprotective effect was evaluated by MTT assay. Results: 4,5-Dimethoxypyrocatechol had neuroprotective effect on the glutamate-induced cellular oxidative death in HT22 cells. Conclusion: Furthermore, we found that reactive oxygen species (ROS) accumulation and calcium concentration by oxidative stress were reduced by 4,5-dimethoxypyrocatechol in HT22 cells.

Keywords:4, 5-dimethoxypyrocatechol, Cynanchum paniculatum, HT22 cells, Neuroprotective effect

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Keywords
4
5-dimethoxypyrocatechol
Cynanchum paniculatum
HT22 cells
Neuroprotective effect
niosomes
neuroprotective effect