Phytochemical Study and Evaluation of Antioxidant, Neuroprotective and Acetylcholinesterase Inhibitor Activities of Galeopsis ladanum L. extracts

Pueyo I Uriarte; MI Calvo

Articles

Abstract

Pharmacognosy Magazine,2009,5,20,287-290.

DOI:10.4103/0973-1296.58146

Published:October 2009

Type:Research Article

Authors:

Pueyo I Uriarte,
and MI Calvo

Author(s) affiliations:

Pueyo I Uriarte, MI Calvo
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, 31008 Pamplona (Navarra), Spain

Abstract:

The antioxidant activity, neuroprotective effect and acetylcholinesterase activity of the dichloromethane, ethyl acetate, methanol and water extracts of seeds, leaves and roots of Galeopsis ladanum L. were investigated. Ethyl acetate, methanol and water extracts of leaves showed the highest antioxidant activity (DPPH). Methanol and water extracts of seeds and the water extract of roots showed neuroprotective effect on hydrogen peroxide induced apoptosis in rat pheochromocytoma PC12 cells. Some dichloromethane, ethyl acetate and water extracts exhibited antiacetylcholinesterase activity by TLC.

Keywords:Galeopsis ladanum ; antioxidant activity ; neuroprotective effect ; PC12 cells ; acetylcholinesterase inhibitors