Hypolipidemic Effects of Seed Extract of Celery (Apium graveolens ) in Rats

Kamal Mansi; Adel M Abushoffa; Ahmad Disi; Talal Aburjai

Articles

Abstract

Pharmacognosy Magazine,2009,5,20,301-305.

DOI:10.4103/0973-1296.58149

Published:December 2009

Type:Research Article

Authors:

Author(s) affiliations:

Kamal Mansi¹, Adel M Abushoffa², Ahmad Disi³, Talal Aburjai⁴
¹Department of Biological Sciences, Faculty of Science, Al al-bayt University, Mafraq, Jordan
²Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alfateh University of Medical Sciences, Tripoli, Libya, P.O.Box 13620, Libya
³Department of Biological Sciences, Faculty of Science, University of Jordan, Amman 11942, Jordan
⁴Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan

Abstract:

The hypolipidemic effects of ethanol extract of A. graveolens L. (Apiaceae) were investigated. Forty adult male albino rats weighing about 260 g each, were divided into four groups (n = 10). Experimental animals were gavaged at doses of 213 and 425 mg/kg body wt. for sixty consecutive days. Extract showed a significant decrease (p<0.05) of serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-c), and significant increase (p<0.05) in high-density lipoprotein cholesterol (HDL-c) in the treated groups. The oral administration of ethanol extract of A. graveolens revealed good hypolipideamic effects in adult male albino rats. The results have given a considerable agreement to the traditional use of A. graveolens in the treatment of hyperlipidemia; it could possibly lead to appropriate changes in blood lipid profiles.

Keywords:Apium graveolens, HDL cholesterol, hyperlipidemia, LDL cholesterol, triglycerides