A questionnaire survey for the analysis of determinants influencing use of Ayurvedic medication was conducted amongst 2000 people from various categories approached at fifty different medical stores in Pune region, asking them to tick the option that they consider while using Ayurvedic medication. Results were calculated using descriptive analysis. 37.30% of people regularly consume Ayurvedic medication up to 50% of their total medication, wherein safety (52%) and faith (33.50%) were found to be the prime reasons for its consumption. The study also found that 58.45% of surveyed people follow physician's prescription and don't accept substituted medicine given by the chemist. A comparatively large number of people (41.55%) go for self medication influenced by various parameters. The use of Ayurvedic medication in pediatric patients and co- administration with allopathic medicine by qualified people is fairly less. The survey revealed that consumption of Ayurvedic medication in Pune region is increasing, wherein safety and faith are important parameters, however, like allopathic medication; people usually stick to the prescription issued by the physician. The increasing trend of self medication and lack of knowledge of herb drug interaction especially in non graduates are the major concerns need to be addressed for better outcome of the therapy.