Studies on diuretic and laxative activity of bark extracts of Spondias pinnata (Linn. f) Kurz

S Mondal; GK Dash; S Acharyya; DK Brahma; S Bal

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Pharmacognosy Magazine,2009,5,19s,28-31.

Published:February 2010

Type:Research Article

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Author(s) affiliations:

S Mondal¹, GK Dash¹, S Acharyya¹, DK Brahma¹, S Bal²
¹Matushree V. B. Manvar College of Pharmacy, Dumiyani, Rajkot district, Gujarat -360 440, India
²ndira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Orissa-751 015, India

Abstract:

The diuretic and laxative activity of different extracts of the barks of Spondias pinnata (Linn. f) Kurz (Family: Rubiaceae) were studied in Wistar albino rats. Furosemide (10 mg/kg, p.o.) and agar-agar (300 mg/kg, p.o.) were used as reference standards respectively for activity comparison. The chloroform and methanol extracts produced significant diuretic and laxative activity. On the other hand, the petroleum ether extract did not reveal significant activity. Urinary levels of sodium, potassium (by flame photometry) and chloride (by titrimetry) were estimated.

Keywords:acute toxicity study, agar-agar, diuretic activity, furosemide, laxative activity, Spondias pinnata

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Mondal S, Dash GK, Acharyya S, Brahma DK, Bal S. Studies on diuretic and laxative activity of bark extracts of Spondias pinnata (Linn. f) Kurz. Pharmacognosy Magazine [Internet]. 2009;5(19s):28-31. http://www.phcog.com/text.asp?2009/5/19/28/59778