Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence

Background: Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases. Objective: To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemical parameters. Materials and Methods: Exposure of mice (30 days old male) to F (120 ppm) daily for 30 days. Result and Discussion: Treatment with the F causes an increase in lipid peroxidation (LPO) and also increase in the neurodegenerative cells in the hippocampal sub-regions. Interestingly, co-treatment with Cur (30 mg/kg BW) with F (120 ppm) for 30 days results in significant decreases in LPO with a concomitant decrease in neurodegeneration as compared with those treated with F alone. Conclusion: Our study reveals that Cur is useful in ameliorating degenerative effects of F in mice brain.