In vitro antileishmanial activity of methanolic extracts for some selected medicinal plants

Ahmed Gomaa Gomaa Darwish; Mamdouh Nabil Samy; Sachiko Sugimoto; Katsuyoshi Matsunami; Hideaki Otsuka

Articles

Abstract

Pharmacognosy Magazine ,2019,15,62,34-37.

DOI:10.4103/pm.pm_570_18

Published:April 2019

Type:Original Article

Authors:

Author(s) affiliations:

Ahmed Gomaa Gomaa Darwish¹, Mamdouh Nabil Samy², Sachiko Sugimoto³, Katsuyoshi Matsunami³, Hideaki Otsuka⁴
¹Department of Biochemistry, Faculty of Agriculture, Minia University, Minia, Egypt; Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
²Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
³Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
⁴Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University; Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women's University, Hiroshima, Japan

Abstract:

Objective: The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants; ten well-known medicinal plants cultivated and growing under African environmental conditions were studied. Materials and Methods: The methanolic extracts of these plants were screened for their antileishmanial activity against Leishmania major using 3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide assay. Results: The methanol extract of Colchicum autumnale and Alpinia officinarum showed potent antileishmanial activity at inhibition% value of 98.29% ± 0.75% and 97.25 ± 1.63%, respectively, while Silybum marianum exhibited inhibition% value of 90.97% ± 1.13%, compared with the standard amphotericin B (89.31% ± 2.08%). Conclusion: Considering these results, medicinal plants from African environment could constitute a developer source for antileishmanial compounds.