Antitumor effects of dammarane-type saponins from steamed Notoginseng

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Abstract
Pharmacognosy Magazine,2014,10,39,314-317.
DOI:10.4103/0973-1296.137372
Published:July 2014
Type:Original Article
Authors:
Author(s) affiliations:

Fan He1, Yan Ding2, Chun Liang3, Seok Bean Song4, De-Qiang Dou1, Gyu Yong Song4, Young Ho Kim4
1 Department of Pharmacognosy, Liaoning University of Traditional Chinese Medicine, Dalian, China
2 Institute of Chemistry and Applications of Plant Resources, Dalian Polytechnic University, Dalian, China
3 Herbal Medicine Improvement Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea
4 College of Pharmacy, Chungnam National University, Daejeon, Korea

Abstract:

Six dammarane-type saponins were extracted from steamed Panax notoginseng. Their chemical structures were identified spectroscopically as ginsenosides Rh1 (1), Rg1 (2), 20 (S)-Rg3 (3), 20 (R)-Rg3 (4), Rb3 (5), and Rb1 (6). Compounds (0.1-10 μM) were tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 (5) showed the most significant activity with an IC50 of 8.2 μM. This compound also inhibited the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells had been treated with TNF-α (10 ng/mL).

Keywords:Antitumor, Dammarane-type ginsenoside, inhibitory activity, Panax notoginseng

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Keywords
Antitumor
Dammarane-type ginsenoside
iInhibitory activity
inhibitory activity
Panax notoginseng
dammarane-type ginsenoside

Cite This Article

Vancouver Style

He F, Ding Y, Liang C, Song SBean, Dou D-Q, Song GYong, et al.. Antitumor effects of dammarane-type saponins from steamed Notoginseng. Pharmacognosy Magazine [Internet]. 2014;10(39):314-317. https://www.ncbi.nlm.nih.gov/pubmed/25210319