Effect of Allium sativum on the phosphoenolpyruvate carboxykinase and pyruvate kinase activity of Haemonchus contortus in vitro

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Abstract
Pharmacognosy Magazine,2009,5,20s,430-432.
Published:February 2010
Type:Research Article
Authors:
Author(s) affiliations:

Lakshmi K Navaneetha, L Veerakumari*
1PG & Research Department of Zoology, Ethiraj College, Chennai, India
2PG & Research Department of Zoology, Unit of Parasitology, Pachaiyappa’s College, Chennai- 600030, Tamil Nadu, India

Abstract:

Effect of Allium sativum bulb extract (AsBE) on the phosphoenolpyruvate carboxykinase (PEP) and pyruvate kinase (PK) activity of Haemonchus contortus was studied.Maximum level of inhibition in both PEPCK and PK activities were observed in worms treated at 10 mg ml-1 concentration of AsBE after 8 h incubation. This inhibition in the enzyme activity affects the energy generating process, which ultimately proves fatal to the parasite.

Keywords:Haemonchus contortus; Allium sativum; phosphoenolpyruvate carboxykinase; pyruvate kinase

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Keywords
Haemonchus contortus; Allium sativum; phosphoenolpyruvate carboxykinase; pyruvate kinase