Chemical Composition and Hepato-protective activity of Imperata cylindrica Beauv

Gamal A Mohamed; Ahmed Abdel-Lateff; Mostafa A Fouad; Sabrin R.M Ibrahim; Ehab S Elkhayat; Tatsufumi Okino

Articles

Abstract

Pharmacognosy Magazine,2009,5,17,28-36.

Published:December 2009

Type:Research Article

Authors:

Author(s) affiliations:

Gamal A. Mohamed ^a , Ahmed Abdel-Lateff ^b , Mostafa A. Fouad ^b , Sabrin R. M. Ibrahim ^c, Ehab S. Elkhayat *^a and Tatsufumi Okino ^d

^aDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.

^bDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.

^cDepartment of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

^dFaculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan

Abstract:

Phytochemical study of the aerial parts of Imperata cylindrica Beauv. (Graminae), growing in Egypt afforded four methoxylated flavonoids 1-4, β-sitosterol-3-O-β-D-glucopyranosyl-6´-tetradecanoate 5, 3-hydroxy-4-methoxybenzaldehyde 6, together with daucosterol, β-sitosterol and α-amyrin 7-9. To the best of our knowledge, this is the first isolation of compounds 1-5 from the genus Imperata. A significant hepato-protective activity had been observed upon co-administration of the methanolic extracts of I. cylindrica with CCl4. The structures were determined using spectroscopic data; 1D (1H and 13C), 2D (HSQC, and HMBC) NMR; MS; UV and IR. KEYWORDS: Methoxylated flavonoids, Imperata cylindrica, steroids, hepato-protective activity.

Keywords:Hepato-protective activity, Imperata cylindrica, Methoxylated flavonoids, steroids