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  Indian J Med Microbiol
 

Figure 2: Effects of bisacurone on RANKL, OPG, Runx2, Osteocalcin, AMPK, and PPAR-γ after fracture in female OVX-induced OP rats. (a). Quantitative representation of the mRNA expression are as follows: (b) RANKL; (c) OPG; (d) Runx2; (e) Osteocalcin; (f) AMPK; (G) PPAR- γ. 1000 base pair ladder of mRNA expression (Lane 1); Sham-operated group mRNA expression (Lane -2); Control group mRNA expression (Lane 3); alendronate 3 mg/kg group mRNA expression (Lane 4); Bisacurone 25, 50, 100 μg/kg groups mRNA expression (Lanes 5–7); and combination of bisacurone 100 μg/kg and alendronate 3 mg/kg group mRNA expression (Lane 8). Data are expressed as mean ± S.E.M. (n = 6) and analyzed by one-way ANOVA followed by the Bonferroni test. *P < 0.05 as compared to the control group, #P < 0.05 as compared to the sham group, $P < 0.05 as compared to one another. Sham: Sham-operated rats; Control: OVX control rats; a (3): Alendronate (3 mg/kg, s.c.)-treated rats; b (25): Bisacurone (25 μg/kg, p.o.)-treated rats; b (50): Bisacurone (50 μg/kg, p.o.)-treated rats; b (100): Bisacurone (100 μg/kg, p.o.)-treated rats; a (3) + b (100): Alendronate (3 mg/kg, s.c.) and Bisacurone (100 μg/kg, p.o.)-treated rats

Figure 2: Effects of bisacurone on RANKL, OPG, Runx2, Osteocalcin, AMPK, and PPAR-γ after fracture in female OVX-induced OP rats. (a). Quantitative representation of the mRNA expression are as follows: (b) RANKL; (c) OPG; (d) Runx2; (e) Osteocalcin; (f) AMPK; (G) PPAR- γ. 1000 base pair ladder of mRNA expression (Lane 1); Sham-operated group mRNA expression (Lane -2); Control group mRNA expression (Lane 3); alendronate 3 mg/kg group mRNA expression (Lane 4); Bisacurone 25, 50, 100 μg/kg groups mRNA expression (Lanes 5–7); and combination of bisacurone 100 μg/kg and alendronate 3 mg/kg group mRNA expression (Lane 8). Data are expressed as mean ± S.E.M. (n = 6) and analyzed by one-way ANOVA followed by the Bonferroni test. *<i>P</i> < 0.05 as compared to the control group, #<i>P</i> < 0.05 as compared to the sham group, $<i>P</i> < 0.05 as compared to one another. Sham: Sham-operated rats; Control: OVX control rats; a (3): Alendronate (3 mg/kg, s.c.)-treated rats; b (25): Bisacurone (25 μg/kg, p.o.)-treated rats; b (50): Bisacurone (50 μg/kg, p.o.)-treated rats; b (100): Bisacurone (100 μg/kg, p.o.)-treated rats; a (3) + b (100): Alendronate (3 mg/kg, s.c.) and Bisacurone (100 μg/kg, p.o.)-treated rats