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  Indian J Med Microbiol
 

Figure 5: ELISA analysis of (a) APG concentration (b) GABA concentration analysis in the hippocampal brain tissue, (c) Western blot analysis of TSPO (18 kDa protein) of the hippocampal brain tissue. Data are represented as the mean + SEM, (n = 8), Comparisons: a = group II, III, IV, V, VI with group I and b = group III, IV, V, VI with group II, Significant: nsP > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001; $P < 0.05; $$P < 0.01 when group IV compared with group III; φφφP < 0.001 when group VI compared with group IV; Group I: CF/SPS (No stress + vehicle), Group II: CF+/SPS+ (stress + vehicle), Group III: CF+/SPS+−TnCE100 (stress + TnCE treatment, 100 mg/kg, b.w., p.o); Group IV: CF+/SPS+−TnC200 (stress + TnC treatment, 200 mg/kg, b.w., p.o), Group V: CF+/SPS+ −SeR15 (stress + SeR, 15 mg/kg, b.w., p.o), Group VI: CF+/SPS+−PK + TnCE [stress + PK11195 (3 mg/kg, b.w.; i.p)+TnCE (200 mg/kg, b.w., p.o)], SPS: single prolonged stress, CF: Conditioned fear, TnCE: Tinospora cordifolia (ethanolic extract); SeR: Sertraline, APG: Allopregnanolone, TSPO: Translocator protein, PK11195: TSPO antagonist

Figure 5: ELISA analysis of (a) APG concentration (b) GABA concentration analysis in the hippocampal brain tissue, (c) Western blot analysis of TSPO (18 kDa protein) of the hippocampal brain tissue. Data are represented as the mean + SEM, (<i>n</i> = 8), Comparisons: a = group II, III, IV, V, VI with group I and b = group III, IV, V, VI with group II, Significant: <sup>ns</sup><i>P</i> > 0.05; *<i>P</i> < 0.05; **<i>P</i> < 0.01; ***<i>P</i> < 0.001; <sup>$</sup><i>P</i> < 0.05; <sup>$$</sup><i>P</i> < 0.01 when group IV compared with group III; φφφ<i>P</i> < 0.001 when group VI compared with group IV; Group I: CF<sup>−</sup>/SPS<sup>−</sup> (No stress + vehicle), Group II: CF<sup>+</sup>/SPS<sup>+</sup> (stress + vehicle), Group III: CF<sup>+</sup>/SPS<sup>+</sup>−TnCE<sub>100</sub> (stress + TnCE treatment, 100 mg/kg, b.w., p.o); Group IV: CF<sup>+</sup>/SPS<sup>+</sup>−TnC<sub>200</sub> (stress + TnC treatment, 200 mg/kg, b.w., p.o), Group V: CF<sup>+</sup>/SPS<sup>+</sup> −SeR<sub>15</sub> (stress + SeR, 15 mg/kg, b.w., p.o), Group VI: CF<sup>+</sup>/SPS<sup>+</sup>−PK + TnCE [stress + PK11195 (3 mg/kg, b.w.; i.p)+TnCE (200 mg/kg, b.w., p.o)], SPS: single prolonged stress, CF: Conditioned fear, TnCE: <i>Tinospora cordifolia</i> (ethanolic extract); SeR: Sertraline, APG: Allopregnanolone, TSPO: Translocator protein, PK11195: TSPO antagonist