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  Indian J Med Microbiol
 

Figure 3: Effects of TnCE extract administration on (A) CF + SPS–induced conditioned fear response to context exposure, (B) Immobility time in forced swimming test, (C) on locomotor activity (open field test) measured in terms of (i) distance travelled crossings, (ii) crossings and (iii) rear. Data are represented as the mean ± SEM, (n = 8), Comparisons: a = group II, III, IV, V, VI with group I and b = group III, IV, V, VI with group II, Significant: nsP > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001; $P < 0.05; $$P < 0.01 when group IV compared with group III; φφφP < 0.001 when group VI compared with group IV; Group I: CF/SPS (No stress + vehicle), Group II: CF+/SPS+ (stress + vehicle), Group III: CF+/SPS+−TnCE100 (stress + TnCE treatment, 100 mg/kg, b.w., p.o); Group IV: CF+/SPS+−TnC200 (stress + TnC treatment, 200 mg/kg, b.w., p.o), Group V: CF+/SPS+ −SeR15 (stress + SeR, 15 mg/kg, b.w., p.o), Group VI: CF+/SPS+−PK + TnCE [stress + PK11195 (3 mg/kg, b.w.; i.p)+TnCE (200 mg/kg, b.w., p.o)], SPS: single prolonged stress, CF: Conditioned fear, TnCE: Tinospora cordifolia (ethanolic extract); SeR: Sertraline, APG: Allopregnanolone, TSPO: Translocator protein, PK11195: TSPO antagonist

Figure 3: Effects of TnCE extract administration on (A) CF + SPS–induced conditioned fear response to context exposure, (B) Immobility time in forced swimming test, (C) on locomotor activity (open field test) measured in terms of (i) distance travelled crossings, (ii) crossings and (iii) rear. Data are represented as the mean ± SEM, (<i>n</i> = 8), Comparisons: a = group II, III, IV, V, VI with group I and b = group III, IV, V, VI with group II, Significant: <sup>ns</sup><i>P</i> > 0.05; *<i>P</i> < 0.05; **<i>P</i> < 0.01; ***<i>P</i> < 0.001; <sup>$</sup><i>P</i> < 0.05; <sup>$$</sup><i>P</i> < 0.01 when group IV compared with group III; φφφ<i>P</i> < 0.001 when group VI compared with group IV; Group I: CF<sup>−</sup>/SPS<sup>−</sup> (No stress + vehicle), Group II: CF<sup>+</sup>/SPS<sup>+</sup> (stress + vehicle), Group III: CF<sup>+</sup>/SPS<sup>+</sup>−TnCE<sub>100</sub> (stress + TnCE treatment, 100 mg/kg, b.w., p.o); Group IV: CF<sup>+</sup>/SPS<sup>+</sup>−TnC<sub>200</sub> (stress + TnC treatment, 200 mg/kg, b.w., p.o), Group V: CF<sup>+</sup>/SPS<sup>+</sup> −SeR<sub>15</sub> (stress + SeR, 15 mg/kg, b.w., p.o), Group VI: CF<sup>+</sup>/SPS<sup>+</sup>−PK + TnCE [stress + PK11195 (3 mg/kg, b.w.; i.p)+TnCE (200 mg/kg, b.w., p.o)], SPS: single prolonged stress, CF: Conditioned fear, TnCE: <i>Tinospora cordifolia</i> (ethanolic extract); SeR: Sertraline, APG: Allopregnanolone, TSPO: Translocator protein, PK11195: TSPO antagonist