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  Indian J Med Microbiol
 

Figure 2: Social interaction effects of TnCE treatment in CF+SPS stress-induced animal. 2A (i and ii) represents comparison between number of entries as well as time elapsed in area of empty and occupied cup; 2B (i and ii) represents comparison between number of entries as well as time elapsed in arena surrounding empty and occupied cup; data are represented as the mean ± SEM (n = 8). Unpaired t-test was employed for the assessment of sociability within each group; 2c represents total distance travelled by animals. One-way ANOVA followed by Bonferroni test was used for analysis by comparing groups III, IV, V, VI with group II, Significant: nsP > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001; nsP > 0.05 when group IV is compared with group III, nsP > 0.05 when group VI is compared with group IV; Group I: CF/SPS (No stress + vehicle), Group II: CF+/SPS+ (stress + vehicle), Group III: CF+/SPS+−TnCE100 (stress + TnCE treatment, 100 mg/kg, b.w., p.o); Group IV: CF+/SPS+−TnC200 (stress + TnC treatment, 200 mg/kg, b.w., p.o), Group V: CF+/SPS+ −SeR15 (stress + SeR, 15 mg/kg, b.w., p.o), Group VI: CF+/SPS+−PK + TnCE [stress + PK11195 (3 mg/kg, b.w.; i.p)+TnCE (200 mg/kg, b.w., p.o)], SPS: single prolonged stress, CF: Conditioned fear, TnCE: Tinospora cordifolia (ethanolic extract); SeR: Sertraline, APG: Allopregnanolone, TSPO: Translocator protein, PK11195: TSPO antagonist

Figure 2: Social interaction effects of TnCE treatment in CF+SPS stress-induced animal. 2A (i and ii) represents comparison between number of entries as well as time elapsed in area of empty and occupied cup; 2B (i and ii) represents comparison between number of entries as well as time elapsed in arena surrounding empty and occupied cup; data are represented as the mean ± SEM (<i>n</i> = 8). Unpaired <i>t</i>-test was employed for the assessment of sociability within each group; 2c represents total distance travelled by animals. One-way ANOVA followed by Bonferroni test was used for analysis by comparing groups III, IV, V, VI with group II, Significant: <sup>ns</sup><i>P</i> > 0.05; *<i>P</i> < 0.05; **<i>P</i> < 0.01; ***<i>P</i> < 0.001; <sup>ns</sup><i>P</i> > 0.05 when group IV is compared with group III, <sup>ns</sup><i>P</i> > 0.05 when group VI is compared with group IV; Group I: CF<sup>−</sup>/SPS<sup>−</sup> (No stress + vehicle), Group II: CF<sup>+</sup>/SPS<sup>+</sup> (stress + vehicle), Group III: CF<sup>+</sup>/SPS<sup>+</sup>−TnCE<sub>100</sub> (stress + TnCE treatment, 100 mg/kg, b.w., p.o); Group IV: CF<sup>+</sup>/SPS<sup>+</sup>−TnC<sub>200</sub> (stress + TnC treatment, 200 mg/kg, b.w., p.o), Group V: CF<sup>+</sup>/SPS<sup>+</sup> −SeR<sub>15</sub> (stress + SeR, 15 mg/kg, b.w., p.o), Group VI: CF<sup>+</sup>/SPS<sup>+</sup>−PK + TnCE [stress + PK11195 (3 mg/kg, b.w.; i.p)+TnCE (200 mg/kg, b.w., p.o)], SPS: single prolonged stress, CF: Conditioned fear, TnCE: <i>Tinospora cordifolia</i> (ethanolic extract); SeR: Sertraline, APG: Allopregnanolone, TSPO: Translocator protein, PK11195: TSPO antagonist