Close  
Figure 7: Effect of deguelin on matrix metalloproteinase2 expression by immunohistochemical analysis of colon tissues of dextran sulfate sodiuminduced colitic mice. (a) Control animals displayed slight matrix metalloproteinase2 expression (GroupI). A drastically elevated expression pattern of matrix metalloproteinase2 was noted in the dextran sulfate sodiumprovoked colitic mice (GroupII). Deguelin treated colitic mice revealed nearly very least matrix metalloproteinase2 expression (GroupIII). Sulfasalazinetreated mice also displayed the nearnormal expression of matrix metalloproteinase2 (GroupIV). (b) The graphical representation of matrix metalloproteinase2 expression in the colon tissues of experimental animals. All values are depicted as mean ± standard deviation (n = 6). The level of statistical significance was calculated by oneway ANOVA followed by the DMRT test; note: *P < 0.05 when compared with the control group and **P < 0.05 when compared with dextran sulfate sodiumtreated group 
