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  Indian J Med Microbiol
 

Figure 3: Photomicrograph of thoracic aortas from CN, HCD, ZPI, ZPII, and ZPIII groups symbolize immunoflourescent staining with RAM-11 antibody. Control group shows no immunopositive reaction. HCD group demonstrates pronounced IPFCs with increasing intensity and percentage of greenish-fluorochrome foam cells in the intimal plaque (p). Aortas in ZPI, II and III groups demonstrate a significant reduction in the macrophage-derived foam cells within the tunica intima compare to HCD group, indicated by the low intensity of greenish-fluorochrome immunopositive RAM-11 cells in the intimal plaque (p) (white arrows). Bar graph represents (IPFC) and (INNFC) cells of macrophage-specific protein biomarker RAM-11. *indicates statistical significance compared to HCD at P < 0.05. L: Lumen; M: Media; A: Adventitia. Scale bars: 200 μm. CN: Control group; RAM-11: Regulation of ACE2 and morphogenesis 11; ZP: ZER-preventive; ZER: Zerumbone; IPC: Immunoreactive-positive cells; INC: Immunoreactive-negative cells; IPFC: Immunopositive fluorescent cells; INNFC: Immunonegative nonfluorescent cells

Figure 3: Photomicrograph of thoracic aortas from CN, HCD, ZPI, ZPII, and ZPIII groups symbolize immunoflourescent staining with RAM-11 antibody. Control group shows no immunopositive reaction. HCD group demonstrates pronounced IPFCs with increasing intensity and percentage of greenish-fluorochrome foam cells in the intimal plaque (p). Aortas in ZPI, II and III groups demonstrate a significant reduction in the macrophage-derived foam cells within the tunica intima compare to HCD group, indicated by the low intensity of greenish-fluorochrome immunopositive RAM-11 cells in the intimal plaque (p) (white arrows). Bar graph represents (IPFC) and (INNFC) cells of macrophage-specific protein biomarker RAM-11. *indicates statistical significance compared to HCD at<i> P </i>< 0.05. L: Lumen; M: Media; A: Adventitia. Scale bars: 200 μm. CN: Control group; RAM-11: Regulation of ACE2 and morphogenesis 11; ZP: ZER-preventive; ZER: Zerumbone; IPC: Immunoreactive-positive cells; INC: Immunoreactive-negative cells; IPFC: Immunopositive fluorescent cells; INNFC: Immunonegative nonfluorescent cells