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  Indian J Med Microbiol
 

Figure 5: P53 was a candidate target gene of miR-122 (*P < 0.05, vs. control group). (a) P53 was identified as the candidate target gene of miR-122 in osteoblast with the “seed sequence” in the 3' untranslated region of P53. (b) Luciferase activity of wild-type P53 3' untranslated region but not that of mutant P53 3' untranslated region in osteoblast was reduced by transfecting with miR-122 mimic. (c) MG-63 cells transfected with miR-122 mimic exhibited a lower luciferase activity of wild-type P53 3' untranslated region

Figure 5: P53 was a candidate target gene of miR-122 (*<i>P</i> < 0.05, vs. control group). (a) P53 was identified as the candidate target gene of miR-122 in osteoblast with the “seed sequence” in the 3' untranslated region of P53. (b) Luciferase activity of wild-type P53 3' untranslated region but not that of mutant P53 3' untranslated region in osteoblast was reduced by transfecting with miR-122 mimic. (c) MG-63 cells transfected with miR-122 mimic exhibited a lower luciferase activity of wild-type P53 3' untranslated region