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  Indian J Med Microbiol
 

Figure 6: MiR-221 directly regulated RUNX2 (*P < 0.05, vs. control group). (a) The 3'-UTR of RUNX2 is targeted by miR-221 with potential “hit” in the 3' untranslated region of RUNX2. (b) Luciferase activity of wild-type RUNX2 3' untranslated region but not that of mutant RUNX2 3' untranslated region in osteoblast was reduced by transfecting with miR-221 mimic. (c) MG-63 cells transfected with miR-221 mimic exhibited a lower luciferase activity of wild-type RUNX2 3' untranslated region

Figure 6: MiR-221 directly regulated RUNX2 (*<i>P</i> < 0.05, vs. control group). (a) The 3'-UTR of RUNX2 is targeted by miR-221 with potential “hit” in the 3' untranslated region of RUNX2. (b) Luciferase activity of wild-type RUNX2 3' untranslated region but not that of mutant RUNX2 3' untranslated region in osteoblast was reduced by transfecting with miR-221 mimic. (c) MG-63 cells transfected with miR-221 mimic exhibited a lower luciferase activity of wild-type RUNX2 3' untranslated region