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  Indian J Med Microbiol
 

Figure 5: Effect of Ecklonia cava polyphenols on intraneural accumulation of sorbitol in the sciatic nerves of diabetic animals. Sorbitol concentration in the nerve homogenates was estimated by analytical high-performance liquid chromatography employing a gradient program of mobile phase (CH3CN and H2O) with a flow of 1.0 mL/min against a standard sorbitol solution (100 μg/mL). Sorbitol concentration was determined by quantifying the area under the curve of sorbitol peak. Values are expressed as mean ± standard error of the mean (n = 6). ***P < 0.001 compared with normal controls, ###P < 0.001 compared with diabetic peripheral neuropathy control

Figure 5: Effect of <i>Ecklonia cava</i> polyphenols on intraneural accumulation of sorbitol in the sciatic nerves of diabetic animals. Sorbitol concentration in the nerve homogenates was estimated by analytical high-performance liquid chromatography employing a gradient program of mobile phase (CH<sub>3</sub>CN and H<sub>2</sub>O) with a flow of 1.0 mL/min against a standard sorbitol solution (100 μg/mL). Sorbitol concentration was determined by quantifying the area under the curve of sorbitol peak. Values are expressed as mean ± standard error of the mean (<i>n</i> = 6). ***<i>P</i> < 0.001 compared with normal controls, ###<i>P</i> < 0.001 compared with diabetic peripheral neuropathy control