Close
  Indian J Med Microbiol
 

Figure 4: Docking results (a) Surface representation (side-view) of 1 at the main binding site of IGF1R (Protein data bank ID 2OJ9) (b) Key interactions of1 and IGF1R at main site, (c) Key interactions of 1 at the allosteric site (Protein data bank ID 3 LW0). Interaction map shows the absence of key residue (Val1063) even in the close vicinity of 1. (d) Key interactions between benzimidazole inhibitor and active site residues of IGF1R (Protein data bank ID 2OJ9). Legend: solid pink lines-interactions with amino acid backbone, broken pink lines-interactions with amino acid side-chains, residues color based on their nature

Figure 4: Docking results (a) Surface representation (side-view) of 1 at the main binding site of IGF1R (Protein data bank ID 2OJ9) (b) Key interactions of1 and IGF1R at main site, (c) Key interactions of 1 at the allosteric site (Protein data bank ID 3 LW0). Interaction map shows the absence of key residue (Val1063) even in the close vicinity of 1. (d) Key interactions between benzimidazole inhibitor and active site residues of IGF1R (Protein data bank ID 2OJ9). Legend: solid pink lines-interactions with amino acid backbone, broken pink lines-interactions with amino acid side-chains, residues color based on their nature