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  Indian J Med Microbiol
 

Figure 3: Effects of morin on FCA-induced alterations in hepatic TNF-α, IL-1β, IL-6, Nrf-2, HO-1 and TGF-β messenger RNA expression in rats (a), quantitative representation of the messenger RNA expression of TNF-α (b), IL-1β (c), IL-6 (d), Nrf-2 (e), HO-1 (f), and TGF-β (g). Data are expressed as mean ± standard error of the mean (n = 5) and analyzed by one-way ANOVA followed by Tukey's multiple range test. #P < 0.05 as compared to normal group, *P < 0.05 as compared to the AIA-control group, and $p < 0.05 as compared to one another. Lane 1: Ladder 1000 bp; Lane 2: Messenger RNA expression of normal group; Lane 3: messenger RNA expression of AIA control group; Lane 4: messenger RNA expression of Leflunomide (10 mg/kg)-treated group, and Lane 5-7: messenger RNA expression of Morin (10, 30, and 100 mg/kg)-treated group. AIA: Adjuvant-induced arthritis; LF: Leflunomide; M: Morin; TNF-α: Tumor necrosis factor-alpha; IL-1β: Interleukin-1 beta; Nrf2: Nuclear factor erythroid 2-related factor-2; HO-1: Heme Oxygenase-1; TGF-β: Transforming growth factor-beta

Figure 3: Effects of morin on FCA-induced alterations in hepatic TNF-α, IL-1β, IL-6, Nrf-2, HO-1 and TGF-β messenger RNA expression in rats (a), quantitative representation of the messenger RNA expression of TNF-α (b), IL-1β (c), IL-6 (d), Nrf-2 (e), HO-1 (f), and TGF-β (g). Data are expressed as mean ± standard error of the mean (<i>n</i> = 5) and analyzed by one-way ANOVA followed by Tukey's multiple range test. <sup>#</sup><i>P</i> < 0.05 as compared to normal group, *<i>P</i> < 0.05 as compared to the AIA-control group, and <sup>$</sup><i>p</i> < 0.05 as compared to one another. Lane 1: Ladder 1000 bp; Lane 2: Messenger RNA expression of normal group; Lane 3: messenger RNA expression of AIA control group; Lane 4: messenger RNA expression of Leflunomide (10 mg/kg)-treated group, and Lane 5-7: messenger RNA expression of Morin (10, 30, and 100 mg/kg)-treated group. AIA: Adjuvant-induced arthritis; LF: Leflunomide; M: Morin; TNF-α: Tumor necrosis factor-alpha; IL-1β: Interleukin-1 beta; Nrf2: Nuclear factor erythroid 2-related factor-2; HO-1: Heme Oxygenase-1; TGF-β: Transforming growth factor-beta