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  Indian J Med Microbiol
 

Figure 2: Effect of simvastatin (Sim) on nitric oxide generation in activated highly aggressive proliferating immortalized rat microglial, macrophage cells, and primary astrocytes cells. Microglial cells pretreated with simvastatin for 30 min, and then lipopolysaccharide or lipopolysaccharide/interferon-γ was added and cultured for 24 h. Nitrite generation in culture media (a) highly aggressive proliferating immortalized cell; (b) RAW 264.7 murine macrophage; (c) primary astrocytes was determined using Griess assay. Data represent mean ± standard deviation of at least three independent experiments. Lipopolysaccharide-treated cells compared to simvastatin-treated cells. Symbol mark indicates significant differences from lipopolysaccharide alone treatment group (*P < 0.05)

Figure 2: Effect of simvastatin (Sim) on nitric oxide generation in activated highly aggressive proliferating immortalized rat microglial, macrophage cells, and primary astrocytes cells. Microglial cells pretreated with simvastatin for 30 min, and then lipopolysaccharide or lipopolysaccharide/interferon-γ was added and cultured for 24 h. Nitrite generation in culture media (a) highly aggressive proliferating immortalized cell; (b) RAW 264.7 murine macrophage; (c) primary astrocytes was determined using Griess assay. Data represent mean ± standard deviation of at least three independent experiments. Lipopolysaccharide-treated cells compared to simvastatin-treated cells. Symbol mark indicates significant differences from lipopolysaccharide alone treatment group (*<i>P</i> < 0.05)