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  Indian J Med Microbiol
 

Figure 3: Effect of TAX on mRNA expressions of AhR, CYP1A1, and CYP1B1 in mammary carcinogenesis animals. RNA was extracted from breast tissue and the analysis of reverse transcription-quantitative polymerase chain reaction was carried out with specific primer sequences for AhR (a), CYP1A1 (b), CYP1B1 (c), and GAPDH (control). Relative expressions were expressed as fold induction above control after normalization; each column represents the mean standard error of the mean (n = 3), ***P < 0.001; *P < 0.05 when compared with control. Group I - Control; Group II - DMBA (20 mg); Group III - DMBA (20 mg) + TAX (10 mg/kg b. w.); Group IV – DMBA (20 mg) + TAX (20 mg/kg b. w.); Group V - DMBA (20 mg) + TAX (40 mg/kg b. w.). TAX: Taxifolin, DMBA: 7,12-dimethylbenz(a) anthracene

Figure 3: Effect of TAX on mRNA expressions of AhR, CYP1A1, and CYP1B1 in mammary carcinogenesis animals. RNA was extracted from breast tissue and the analysis of reverse transcription-quantitative polymerase chain reaction was carried out with specific primer sequences for AhR (a), CYP1A1 (b), CYP1B1 (c), and GAPDH (control). Relative expressions were expressed as fold induction above control after normalization; each column represents the mean standard error of the mean (<i>n</i> = 3), ***<i>P</i> < 0.001; *<i>P</i> < 0.05 when compared with control. Group I - Control; Group II - DMBA (20 mg); Group III - DMBA (20 mg) + TAX (10 mg/kg b. w.); Group IV – DMBA (20 mg) + TAX (20 mg/kg b. w.); Group V - DMBA (20 mg) + TAX (40 mg/kg b. w.). TAX: Taxifolin, DMBA: 7,12-dimethylbenz(a) anthracene