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  Indian J Med Microbiol
 

Figure 2: (a) Treatment protocol for in vivo studies. (b) Tumorigenesis assessment in control and taxifolin-treated experimental animals. Isolated tumor tissue from all cancer bearing treatment groups; (c) tumor volume in all treatment groups. (d) Effect of taxifolin treatment on body weight in cancer-inducing animals. Data represented as mean standard error of the mean (n = 10); where ***P < 0.001; **P < 0.01; *P < 0.05; nsp > 0.05; Group II - 7,12-dimethylbenz(a) anthracene (20 mg); Group III - 7,12-dimethylbenz (a) anthracene (20 mg) + taxifolin (10 mg/kg b. w.); Group IV - 7,12-dimethylbenz (a) anthracene (20 mg) + taxifolin (20 mg/kg b. w.); Group V - 7,12-dimethylbenz(a) anthracene (20 mg) + taxifolin (40 mg/kg b. w.). (e) Effect of TAX on CYP1A1 inhibition in vitro. CYP1A1 activity was determined by a luciferase assay with CYP1A1 substrate. All experiments were performed in triplicate. Bars indicate mean ± standard deviation * P < 0.05 versus the control

Figure 2: (a) Treatment protocol for <i>in vivo</i> studies. (b) Tumorigenesis assessment in control and taxifolin-treated experimental animals. Isolated tumor tissue from all cancer bearing treatment groups; (c) tumor volume in all treatment groups. (d) Effect of taxifolin treatment on body weight in cancer-inducing animals. Data represented as mean standard error of the mean (<i>n</i> = 10); where ***<i>P</i> < 0.001; **<i>P</i> < 0.01; *<i>P</i> < 0.05; nsp > 0.05; Group II - 7,12-dimethylbenz(a) anthracene (20 mg); Group III - 7,12-dimethylbenz (a) anthracene (20 mg) + taxifolin (10 mg/kg b. w.); Group IV - 7,12-dimethylbenz (a) anthracene (20 mg) + taxifolin (20 mg/kg b. w.); Group V - 7,12-dimethylbenz(a) anthracene (20 mg) + taxifolin (40 mg/kg b. w.). (e) Effect of TAX on CYP1A1 inhibition <i>in vitro</i>. CYP1A1 activity was determined by a luciferase assay with CYP1A1 substrate. All experiments were performed in triplicate. Bars indicate mean ± standard deviation * <i>P</i> < 0.05 versus the control