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  Indian J Med Microbiol
 

Figure 1: UPLC-MS/MS chromatograms of (A) blank plasma, (B) blank plasma spiked with berberine (0.4 ng/mL), jatrorrhizine (0.4 ng/mL), palmatine (0.4 ng/mL) at LLOQ and carbamazepine (IS, 1μg/mL), (C) plasma sample obtained 1h after a single oral administration of BRC extract. (1) berberine, (2) jatrorrhizine, (3) palmatine, (IS) carbamazepine. The retention time of berberine, jatrorrhizine, palmatine and IS was 3.03 min, 2.69 min, 2.96 min and 3.27 min, respectively.

Figure 1: UPLC-MS/MS chromatograms of (A) blank plasma, (B) blank plasma spiked with berberine (0.4 ng/mL), jatrorrhizine (0.4 ng/mL), palmatine (0.4 ng/mL) at LLOQ and carbamazepine (IS, 1μg/mL), (C) plasma sample obtained 1h after a single oral administration of BRC extract. (1) berberine, (2) jatrorrhizine, (3) palmatine, (IS) carbamazepine. The retention time of berberine, jatrorrhizine, palmatine and IS was 3.03 min, 2.69 min, 2.96 min and 3.27 min, respectively.