Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 69  |  Page : 382--385

Antiviral assessments of honeybee (Apis mellifera L.) venom


Sang Mi Han1, Se Gun Kim1, Hyo Young Kim1, Hong Min Choi1, Hyo Jung Moon1, Soon Ok Woo1, Sok Cheon Pak2 
1 Department of Agricultural Biology, National Institute of Agricultural Sciences, Wanju, Korea
2 School of Biomedical Sciences, Charles Sturt University, Bathurst, Australia

Correspondence Address:
Sang Mi Han
Department of Agricultural Biology, National Institute of Agricultural Sciences, Wanju 55365
Korea

Background: The poultry industry has long been challenged by avian influenza which causes significant economic loss due to decreased egg production and quality. In addition, the notable ability of influenza viruses to develop resistance to conventional antibiotics is one of the biggest tasks that the industry currently faces. Attempts have been made to treat this bird flu with multiple approaches, but effective natural solutions remain elusive. Bee venom (BV) is used for the treatment of various human diseases due to its known anti-inflammatory and antibacterial properties. Recent studies suggest that antimicrobial peptides discovered in BV may be utilized as tools for the design of structurally novel antiviral agents effective against influenza viruses. Materials and Methods: In the present study, we purified BV containing 63.9% ± 5.4% melittin, 10.9% ± 1.6% phospholipase A2, and 2.3% ± 0.3% apamin. BV was evaluated in vitro for its ability to inhibit the binding of H9N2 to the chicken red blood cells. Results: We found that anti-influenza activity of BV is equivalent to that of positive control. However, we observed the neutralization of H9N2 by BV as compared to the virus only group without BV. The hypothesized anti-influenza property of BV was further examined in chicken influenza infection model. The administration of BV through intranasal route resulted in no significant antiviral effect in chickens. Conclusion: This study does not support our hypothesis that BV can reduce the viral activity in chickens.


How to cite this article:
Han SM, Kim SG, Kim HY, Choi HM, Moon HJ, Woo SO, Pak SC. Antiviral assessments of honeybee (Apis mellifera L.) venom.Phcog Mag 2020;16:382-385


How to cite this URL:
Han SM, Kim SG, Kim HY, Choi HM, Moon HJ, Woo SO, Pak SC. Antiviral assessments of honeybee (Apis mellifera L.) venom. Phcog Mag [serial online] 2020 [cited 2022 May 23 ];16:382-385
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2020;volume=16;issue=69;spage=382;epage=385;aulast=Han;type=0