Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 5  |  Page : 566--572

Protective effect of Viburnum grandiflorum against ultraviolet-B radiation-induced cellular and molecular changes in human epidermal keratinocytes


Hanjun Liu1, Haixiu Zhang2, Minyan Dang3, Yukiat Lin3, Hui Yan4,  
1 Department of Dermatology, Hanzhong People's Hospital, Hanzhong, Shaanxi 723000, China
2 Department of Dermatology, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan, Shandong 250012, China
3 Innoscience Research Sdn Bhd, Selangor, Malaysia
4 Department of Dermatology, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, China

Correspondence Address:
Hui Yan
Department of Dermatology, The Second Peoplefs Hospital of Yunnan Province, Kunming, Yunnan 650021
China

Abstract

The aim of the present study was to evaluate the photoprotective potential of Viburnum grandiflorum (VG) against ultraviolet-B radiation-induced responses in HaCaT cells. The HaCaT cells were pretreated with VG prior ultraviolet-B (UVB)-radiation exposure and were further examined for lipid peroxidation, enzymatic antioxidant activity, % reactive oxygen species, DNA damage, mitochondrial membrane potential and for inflammatory, and apoptotic signaling markers such as tumor necrosis factor-alpha, nuclear factor kappa B, interleukin-1 (IL-1), IL-6, cyclooxygenase-2, p53, caspase-3/9, cytochrome-c, Bax, and Bcl-2. The VG pretreatment in UVB exposed cells shows significantly regulated both inflammatory as well as apoptotic signaling cascades. Our findings suggest that VG may be functional against UVB-induced photo-damages.



How to cite this article:
Liu H, Zhang H, Dang M, Lin Y, Yan H. Protective effect of Viburnum grandiflorum against ultraviolet-B radiation-induced cellular and molecular changes in human epidermal keratinocytes.Phcog Mag 2020;16:566-572


How to cite this URL:
Liu H, Zhang H, Dang M, Lin Y, Yan H. Protective effect of Viburnum grandiflorum against ultraviolet-B radiation-induced cellular and molecular changes in human epidermal keratinocytes. Phcog Mag [serial online] 2020 [cited 2022 May 26 ];16:566-572
Available from: http://www.phcog.com/text.asp?2020/16/5/566/301883


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