Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 16  |  Issue : 5  |  Page : 492--497

Effect of Vitex pinnata L. leaf extract on estrogenic activity and lipid profile in ovariectomized rats


Wilawan Promprom1, Wannachai Chatan1, Phukphon Munglue2 
1 Department of Biology, Faculty of Science, Mahasarakham University, Kantharawichai District, Maha Sarakham, Thailand
2 Department of Biology, Faculty of Science, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand

Correspondence Address:
Wilawan Promprom
Department of Biology, Faculty of Science, Mahasarakham University, Kantharawichai District, Maha Sarakham, 44150
Thailand

Background: The genus Vitex contains about 300 species distributed around the world. These genuses are used in the treatment of premenstrual syndrome. However, their estrogenic activity is not well understood. Objectives: To compare the estrogenic activity and lipid profile of ethanol extracts of leaves of Vitex pinnata L. with 17 β-estradiol in bilaterally ovariectomized (OVX) rats. Methods: Ethanol extracts were analyzed by gas chromatography-mass spectrometry (GC-MS). Bilaterally OVX rats were divided into five groups,(n = 6) receiving different treatments, consisting of a vehicle (1% Tween), ethanol extract of V. pinnata at three different doses (100, 500, 1000 mg/kg) and standard drug, 17 β-estradiol at a dose of 1 mg/kg. All groups were administered orally, daily for 14 days. Results: GC-MS data revealed that the major chemical constituents of the extract were 3, 7, 11, 15-Tetramethylhexadecen-2-en-1-ol, Gamma-Stigmasterol, 9,12,15-octadecatrienoic acid and n-hexadecanoic acid. V. pinnata extracts at 1000 mg/kg slightly increased uterine and vaginal weight and endometrial thickness. Doses of extract at 500 and 1000 mg/kg induced a significant (P < 0.05) decrease of triglycerides and total cholesterol in serum of OVX rats. Conclusion: V. pinnata leaf extract exhibits estrogenic activity and reduces levels of serum triglycerides and cholesterol. The understanding of such activity of V. pinnata leaf extract has benefits for postmenopausal women.


How to cite this article:
Promprom W, Chatan W, Munglue P. Effect of Vitex pinnata L. leaf extract on estrogenic activity and lipid profile in ovariectomized rats.Phcog Mag 2020;16:492-497


How to cite this URL:
Promprom W, Chatan W, Munglue P. Effect of Vitex pinnata L. leaf extract on estrogenic activity and lipid profile in ovariectomized rats. Phcog Mag [serial online] 2020 [cited 2022 May 19 ];16:492-497
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2020;volume=16;issue=5;spage=492;epage=497;aulast=Promprom;type=0