Year : 2016 | Volume
: 12 | Issue : 47 | Page : 198--202
Nanostructured lipid carriers loaded with baicalin: An efficient carrier for enhanced antidiabetic effects
Feng Shi1, Zheng Wei2, Yingying Zhao1, Ximing Xu1
1 Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, PR China
2 Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou, PR China
Context: Recent studies have demonstrated that baicalin has antihyperglycemic effects by inhibiting lipid peroxidation. Baicalin is low hydrophilic and poorly absorbed after oral administration. Thus, a suitable formulation is highly desired to overcome the disadvantages of baicalin. Objective: The objective of this work was to prepare baicalin-loaded nanostructured lipid carriers (B-NLCs) for enhanced antidiabetic effects. Materials and Methods: B-NLCs were prepared by high-pressure homogenization method using Precirol as the solid lipid and Miglyol as the liquid lipid. The properties of the NLCs, such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE), were investigated. The morphology of NLCs was observed by transmission electron microscopy. In addition, drug release and antidiabetic activity were also studied. Results: The results revealed that B-NLCs particles were uniformly in the nanosize range and of spherical morphology with a mean size of 92 ± 3.1 nm, a ZP of −31.35 ± 3.08 mV, and an EE of 85.29 ± 3.42%. Baicalin was released from NLCs in a sustained manner. In addition, B-NLCs showed a significantly higher antidiabetic efficacy compared with baicalin. Conclusion: B-NLCs described in this study are well-suited for the delivery of baicalin.
School of Pharmacy, Jiangsu University, No. 301, Xuefu Road, Jingkou District, Zhenjiang
Abbreviations used: B-NLCs: Baicalin-Loaded Nanostructured Lipid Carriers, B-SUS: Baicalin Water Suspension, EE: Encapsulation Efficiency, FBG: Fasting Blood Glucose, HbAlc: Glycosylated Hemoglobin, HPLC: High-performance Liquid Chromatography; NLCs: Nanostructured Lipid Carriers, PI: Polydispersity Index, SD: Sprague-Dawley, SLNs: Solid lipid nanoparticles, STZ: Streptozotocin, TC: Total cholesterol,
TEM: Transmission Electron Microscope,
TG: Total Triglyceride,
ZP: Zeta Potential.
- Currently, herbal medicines have attracted increasing attention as a complementary approach for type 2 diabetes
- Baicalin has antihyperglycemic effects by inhibiting lipid peroxidation
- A suitable formulation is highly desired to overcome the disadvantages (poor solubility and low bioavailability) of baicalin
- Nanostructured lipid carriers could enhance the antidiabetic effects of baicalin.
|How to cite this article:|
Shi F, Wei Z, Zhao Y, Xu X. Nanostructured lipid carriers loaded with baicalin: An efficient carrier for enhanced antidiabetic effects.Phcog Mag 2016;12:198-202
|How to cite this URL:|
Shi F, Wei Z, Zhao Y, Xu X. Nanostructured lipid carriers loaded with baicalin: An efficient carrier for enhanced antidiabetic effects. Phcog Mag [serial online] 2016 [cited 2022 May 23 ];12:198-202
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2016;volume=12;issue=47;spage=198;epage=202;aulast=Shi;type=0