Exploring the topical gel of Thespesia populnea leaf extract for in vivo wound healing efficacy Asif AH, Mulla SM, Shariff A, Sreeharsha N, Meravanige G, Shiroorkar PN, Basheeruddin Asdaq SM, Anwer MK, Roopashree TS, Karnati RK,

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Exploring the topical gel of Thespesia populnea leaf extract for in vivo wound healing efficacy Afzal H Asif¹, Salim M Mulla², Arshia Shariff³, Nagaraja Sreeharsha⁴, Girish Meravanige⁵, Predeepkumar N Shiroorkar⁵, Syed Mohammed Basheeruddin Asdaq⁶, Md Khalid Anwer⁷, Teeka S Roopashree⁸, Ranjith K Karnati⁹ ¹ Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia ² Department of Pharmaceutics, Alard College of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India ³ Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; Department of Pharmaceutics, Alard College of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, India ⁴ Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, India ⁵ Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia ⁶ Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, Saudi Arabia ⁷ Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Alkharj, Saudi Arabia ⁸ Department of Pharmacognosy, Government College of Pharmacy, Bangalore, Karnataka, India ⁹ Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia Correspondence Address: Nagaraja Sreeharsha, Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa-31982 Source of Support: None, Conflict of Interest: None DOI: 10.4103/pm.pm_25_22

Background/Aim: Thespesia populnea is a plant known for its polyphenol and flavonoid content, which plays a crucial role in wound healing activity. Traditionally, extracts of various parts of T. populnea plant have been used to treat various skin diseases including wound healing. Therefore, we made a topical gel containing alcoholic extracts of the leaves of T. populnea for antimicrobial and wound healing activities. Materials and Methods: Extracts of T. populnea were successfully obtained by Soxhlet extraction. Phytochemical screenings were performed to estimate the presence of different metabolites. Combinations of carbopol and propylene glycol were optimized through 3² factorial design for desirable gel characteristics. Results and discussions: Formulated gel was pale brown in color having viscosity of 90,300 cps with acceptable spreadability and extrudability index. Antimicrobial studies showed inhibition activity. The in vivo wound healing studies demonstrated comparable healing properties with respect to marketed Soframycin gel. Furthermore, histopathological studies on Wistar rats also confirmed the same. Conclusion: It can be concluded that the formulated gel is beneficial in topical applications, which can be a beacon for new skin regeneration and wound healing therapies that focuses on herbal remediation.

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    -  Asif AH
    -  Mulla SM
    -  Shariff A
    -  Sreeharsha N
    -  Meravanige G
    -  Shiroorkar PN
    -  Basheeruddin Asdaq SM
    -  Anwer MK
    -  Roopashree TS
    -  Karnati RK

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