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Effect of Simvastatin on Neuroinflammation in Microglial Cells Via Mitogen-activated Protein Kinase and Nuclear Factor κB Pathways

1 Department of Neurology, Tangshan GongRen Hospital, Tangshan, Hebei Province, PR China
2 Hanzhong Central Hospital, 22 KangFu Road, Hanzhong, Shaanxi Province, PR China
3 Scigen Research and Innovation, Periyar Technology Business Incubator, Thanjavur, Tamil Nadu, India
4 Department of Medical Laboratory Technology, School of Allied health Sciences, Manipal, Manipal Academy of Higher Education, Karnataka, India

Correspondence Address:
Kalaivani Manokaran,
Department of Medical Laboratory Technology, School of Allied Health Sciences, Manipal Academy of Higher Education, Madhav Nagar, Near Tiger Circle, Manipal - 576 104, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_418_17

Background: Activated microglial cells are found in different sorts of the neurodegenerative process including Parkinson and Alzheimer. Suppressing the activated microglial cells developed as a novel procedure for the treatment of neuroinflammation-based neurodegeneration. Materials and Methods: We have investigated the effects of simvastatin on memory impairment and inflammatory cytokines expression induced by transient cerebral ischemia in cultured microglial cells. Results: The lipopolysaccharide (LPS)-activated microglial cells treated with simvastatin 3 μmol has decreased the inflammation which was indicated by the reduced levels of the nitric oxide (NO), tumor necrosis factor-α, interleukin-1 β, cyclooxygenase-2, and inducible NO synthase. Simvastatin also delayed the activation of atomic component nuclear factor-κB, p38 mitogen-activated protein kinase, and the reactive oxygen species in LPS-activated microglial cells. Moreover, simvastatin has provoked the outflow of heme oxygenase-1 in BV-2 microglial cells. Conclusions: The present study showed that the simvastatin antagonizes neuroinflammation and can be a potential restorative operator for treating neuroinflammatory ailments. Abbreviations used: LPS: Lipopolysaccharide, TNF-α: Tumor necrosis factor, NO: Nitric oxide, IL-1β: Interleukin, COX-2: Cyclooxygenase, iNOS: Inducible nitric oxide synthase, MAPK: Mitogen-activated protein kinase, HO-1: Heme oxygenase


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