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ORIGINAL ARTICLE
Year : 2022  |  Volume : 18  |  Issue : 79  |  Page : 738-745

Fracture healing in SD rats' bioactivities of cucumber seed polysaccharides


1 Department of Chinese Medicine Processing, Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China
2 Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China
3 Zhongshan Institude for Drug Discovery, Zhongke Zhongshan Institute of Drug Innovation, Zhongshan, China
4 Department of Chinese Medicine Processing, Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin; Department of Chinese Medicine Processing, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China

Correspondence Address:
Haixue Kuang
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin - 150040
China
Qiuhong Wang
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin - 150040
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_14_22

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Aim/Background: We investigated the composition and structure of intracellular polysaccharides in cucumber seeds (CSs) and their effect on Sprague-Dawley (SD) rats and potential activity for fracture healing. Materials and Methods: Polysaccharides are its main water-soluble active ingredient. The SD rat tibia fracture model was established by surgical method, and the healing effect of cucumber seed polysaccharides (CSPs) on SD rat tibia fracture was preliminarily explored. Through histopathological observation, determination of rat serum indicators alkaline phosphatase (AKP), acid phosphatase (ACP), BGP, X-ray imaging observation, and micro-Computed Tomography (CT) imaging observation at different periods. Results and Conclusion: The results showed that CSP enhanced the activity of osteoblasts, increased the metabolic rate of osteoclasts, increased the secretion of AKP, BGP, and ACP, shortened the fracture healing time of SD rats and effectively promoted the healing of tibial fractures in SD rats.


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