Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2022  |  Volume : 18  |  Issue : 79  |  Page : 641-650

Salvianolic Acid B delays hepatolithiasis through inhibiting the fibrosis of intrahepatic biliary epithelial cells

1 Department of Hepatobiliary Surgery, Harrison International Peace Hospital, Hengshui, Hebei, China
2 Department of Geriatric Medicine, Harrison International Peace Hospital, Hengshui, Hebei, China

Correspondence Address:
Hongbin Bao
Department of Hepatobiliary Surgery, Harrison International Peace Hospital, Hengshui, Hebei - 053000
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_162_21

Rights and Permissions

Background: Hepatolithiasis (HL) is one of the common diseases in hepatobiliary surgery, and bile duct fibrosis is the key step in the pathogenesis of HL. Salvia miltiorrhiza (S. miltiorrhiza) has an inhibitory effect on bile duct fibrosis, but its molecular mechanism remains unclear. Objectives: Our research aimed to clarify the molecular mechanism of S. miltiorrhiza on HL. Materials and Methods: The rats were fed with salvianolic acid B and salvianolic acid B-free lithogenic diet (LD) for 4 weeks to observe the degree of bile duct fibrosis. The expression levels of TNF, IL1B, IL6, and MRP2 in HIBEC stimulated by taurodeoxycholic acid (TDCA) were measured by RT-qPCR and ELISA. E-cadherin and Vimentin expression in HIBEC was detected using immunofluorescence and Western blot. Cell proliferation was detected by CCK8. Results: The fibrosis of the bile duct was the key step of HL. The NF-κB pathway was activated and MRP2 was expressed low in intrahepatic biliary epithelial cells surrounding bile duct stones. Through experiments, salvianolic acid B (Sal B) delays HL via the NF-κB/MRP2 axis. Conclusion: In this research, we confirmed that salvianolic acid B inhibited the HL via the NF-κB/MRP2 axis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded9    
    Comments [Add]    

Recommend this journal