Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2022  |  Volume : 18  |  Issue : 79  |  Page : 627-634

Anti-inflammatory effect of luteolin-7-O-glucoside via the JAK1/STAT6/SOCS1 pathway in ulcerative colitis treatment

1 Department of Gastroenterology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong province, China
2 Shandong University of Traditional Chinese Medicine, China
3 Department of Pathology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong province, China

Correspondence Address:
Lili Chi
Department of Gastroenterology, Afliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_506_21

Rights and Permissions

Background: Luteolin-7-O-glucoside (Lut-7-G) is an effective compound found in plants, such as Patrinia and honeysuckle. It has anti-inflammatory as well as antioxidant properties; however, its anti-inflammatory effect on ulcerative colitis (UC) is hardly understood. Objectives: We evaluated the effects of Lut-7-G in dextran sodium sulfate (DSS)-induced UC in mice models, and then explore the underlying mechanism by studying the JAK1/STAT6/SOCS1 signaling pathway. Materials and Methods: Induction of acute colitis in mice was achieved by feeding 2.5% DSS for 7 days. Bodyweight loss, colon length, disease activity index (DAI) score, and spleen index were determined and hematoxylin-eosin and Periodic Acid-Schiff staining were performed to study the pathological changes in mouse colons. The inflammatory factor levels were determined by ELISA, JAK1, STAT6, and SOCS1 expression in colon tissues by RT-qPCR, and signaling pathway proteins by Western blotting. Results: It was found that treatment with Lut-7-G reduced the effects of colon shortening and weight loss, DAI score, spleen index, as well as colon inflammation. In addition, it significantly decreased DSS-induced overexpression of IL-6, IL-1β, IL-18, as well as TNF-α, and considerably reduced mRNA expression of JAK1 and STAT6 but upregulated the SOCS1 expression. Furthermore, Lut-7-G treatment dose-dependently decreased JAK1 and STAT6 protein expression, and only DSS + Lut-7-G (100 mg/kg) could downregulate p-JAK1 and p-STAT6 expression and upregulate SOCS1 protein expression. Moreover, Lut-7-G (100 mg/kg) was as effective as mesalazine. Conclusion: Lut-7-G may regulate the secretion of inflammatory factors and inhibit inflammatory responses through the JAK1/STAT6/SOCS1 pathway, as a determinant in the treatment of UC.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded22    
    Comments [Add]    

Recommend this journal