Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2022  |  Volume : 18  |  Issue : 78  |  Page : 418-426

Structural characterization and emulsifying properties of a water-soluble Buchanania lanzan gum polysaccharide

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India

Correspondence Address:
K Jayaram Kumar
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi - 835 215, Jharkhand
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_96_22

Rights and Permissions

Background: Buchanania lanzan gum, better known as chironji gum, has been traditionally used as a binder in food preparations. Water-soluble polysaccharides have good emulsifying properties, but the polysaccharide structure elucidation of water soluble chironji gum has not been carried out, and also, its use in emulsion has not been explored. Objectives: The aim of this study is to perform structural characterization of water-soluble polysaccharide isolated from chironji gum (CGPS) and explore its nanoemulsifying properties. Materials and Methods: The water-soluble polysaccharide CGPS was isolated and fractionated by Sepharose 6B column. Structural characterization was investigated by high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), and gas chromatography–mass spectrometry (GC–MS). CGPS-stabilized nanoemulsion was formulated using Miglyol 812, Cremophor RH40, and diclofenac sodium and was evaluated. Results: The polysaccharide fraction had a yield of 33.85% ± 0.88% w/w. HPLC analysis revealed that CGPS consisted of galactose, rhamnose, arabinose, and glucose. CGPS had an average molecular weight of 201 kDa. Analytical studies, including NMR and GC–MS, showed that CGPS had repeating units of → 4)-α-d-Galp (1 → 2)-α-l-Rhap-(1 → with terminal β-d-Glcp (1 → and α-l-Araf (1 → residues. The nanoemulsions prepared with CGPS showed a droplet size ranging from 31.41 ± 0.26 to − 65.30 ± 0.21 nm, and negative zeta potential values were obtained for all the nanoemulsions. In vitro drug release studies of the CGPS nanoemulsion formulation revealed that diclofenac sodium release was delayed in simulated colonic fluid. Conclusion: This study indicates immense potential of CGPS for colon-targeted drug delivery system.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal