Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2022  |  Volume : 18  |  Issue : 78  |  Page : 353-359

Growth stage-specific Accumulation of Cardiac Glycosides in Two Variants of Calotropis gigantea (L.) W.T. Aiton

1 Sophisticated Analytical Instrument Facility and Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
2 Sophisticated Analytical Instrument Facility and Research, CSIR-Central Drug Research Institute, Lucknow; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Dipak Kumar Mishra
Botany Unit, Sophisticated Analytical Instrument Facility and Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh - 226 031
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_525_21

Rights and Permissions

Background: Calotropis gigantea (L.) W.T. Aiton, belonging to the family Apocynaceae, is a source of many bioactive cardiac glycosides. Accumulation of secondary metabolites in plants depends upon various external and internal factors, including the plant age or growth stage. Objectives: The main aim of this study was to identify the correct variant and growth stage of C. gigantea for the maximum yield of targeted metabolites. Materials and Methods: In the present experiment, three different tissues, that is, leaf, stem, and root, of 3–12-month-old white flower variant (WFV) and purple flower variant (PFV) of C. gigantea were investigated to find out the growth stage-specific accumulation pattern of five cardiac glycosides (CGs) and their three genins. Results: Highest concentrations of calotropin, uscharin, and uscharidin were found in the stem of five-month-old WFV. Frugoside and uzarigenin were at peak levels in the stem of a nine-month-old member of the same variant. Calotropagenin and coroglaucigenin were at maximum levels in the root and leaf of 8- and 10-month-old members, respectively, of this variant too. The only CG accumulated at maximum level in the root of 11-month-old PFV was asclepin and its quantity was comparable to 8-month-old WFV root. Conclusion: It was observed that the WFV was superior to PFV, considering the accumulation of most of the CGs. Therefore, it can be concluded that the specific tissues of 5–10-month-old members of WFV are optimum for an economic yield of respective CGs.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded30    
    Comments [Add]    

Recommend this journal