| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 18
| Issue : 78 | Page : 348-352 |
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Goniothalamin alleviates inflammation and arthritic markers in adjuvant-induced arthritis in rats
Dong Yang1, Guangfeng Niu2, Jie Guo3
1 Department of Joint Surgery, The Third Hospital of Jinan, Jinan, China
2 Department of Orthopaedics, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University; Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
3 Department of Spine Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China
Correspondence Address:
Jie Guo
Department of Spine Joint Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/pm.pm_257_21
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Background: Goniothalamin (GTN) is a well-known styryl lactone that possesses anti-inflammatory and anticancer properties. In this study, we evaluated the potential of GTN on experimental arthritis based on the complete Freund's adjuvant (CFA)-induced arthritis model in rats and the effect was compared with standard drug. Materials and Methods: The animals were divided into six groups: normal, CFA, CFA + indomethacin (10 mg/kg bw), CFA + GTN (50 mg/kg bw), CFA + GTN (100 mg/kg bw), and GTN (100 mg/kg bw) alone. The antiarthritic activity of GTN was measured by paw thickness, arthritic score, body weight, organ weight, biochemical markers, inflammatory mediators, and histopathologic analysis of ankle joints. Results: GTN significantly reduced the paw thickness, arthritic score, body weight changes, and organ weight. It reduced the levels of C-reactive protein, alkaline phosphatase, rheumatoid factor, and proinflammatory cytokines in a dose-dependent manner. It also minimized the histopathologic changes in ankle joints induced by CFA in a dose-dependent manner. Conclusion: These results demonstrate that GTN is effective against inflammation and is an alternative agent for the management of arthritis.
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