Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2022  |  Volume : 18  |  Issue : 78  |  Page : 334-340

Oridonin Regulates NF-κB Signaling Pathway in Gestational Diabetes Suppression of SPARC and G6pase in C57BL/6J Mice


Department of Obstetrics, Affiliated Hospital of Hebei University, Baoding, China

Correspondence Address:
Chenyuan Cao
Department of Obstetrics, Affiliated Hospital of Hebei University, Baoding - 071000
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_146_21

Rights and Permissions

Background: In recent years, the morbidity of gestational diabetes (GD) has increased by around 5%–10%, and it now affects around 8%–21% of all births, with around 3%–5% of these women suffering from long-term diabetes after birth. Premature maturation, birth trauma, macrosomia, and respiratory problems are the common complications seen in pregnant women with GD. Lack of glucose tolerance is normally found in pregnant women with GD. Furthermore, GD during pregnancy can result in more complications in the long run, with a high risk of type-2 diabetes developing in subsequent generations. Materials and Methods: C57BL/KsJ mice were used to evaluate the efficacy of oridonin against GD. The animals were divided into four groups: normal mice with pregnancy, GD alone; GD + oridonin (25 mg/kg bw), and GD + oridonin (50 mg/kg bw). After 10 days of gestational period, the following parameters were evaluated: glucose and insulin tolerance in blood, body weight, lipid peroxidation products (thiobarbituric acid reactive substances (TBARS)), and antioxidant markers (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in liver tissues were analyzed. After 20 days of gestational period, the following parameters were measured in the liver tissues by using ELISA kits: elevation of secreted protein acidic and rich in cysteine (SPARC) and pro-inflammatory cytokines. Results: In GD-induced mice, oridonin partially corrected glucose and insulin tolerance and maintained ideal body weight. Moreover, oridonin elevated the levels of SOD, CAT, and GSH and reduced the levels of TBARS in GD mice. Finally, oridonin downregulated the expression of SPARC and nuclear factor kappa B (NF-κB). Conclusion: In summary, oridonin showed an anti-inflammatory antioxidant effect and prevented GD in pregnant mice.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed96    
    Printed4    
    Emailed0    
    PDF Downloaded25    
    Comments [Add]    

Recommend this journal