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ORIGINAL ARTICLE
Year : 2022  |  Volume : 18  |  Issue : 78  |  Page : 286-295

Xylocarpus moluccensis fruit fraction rescues cardiac hypertrophy by improving angiogenesis and regulating NF-κB-mediated inflammation


1 Department of Pharmacology, CSIR-Central Drug Research Institute, Lucknow; Academy of Science and Innovation Research, New Delhi, India
2 Department of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
3 Academy of Science and Innovation Research, New Delhi; Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, India

Correspondence Address:
Kumaravelu Jagavelu
Principal Scientist, Pharmacology Division, CSIR-Central Drug Research Institute, CDRI/B.S.10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_79_21

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Background and Aim: The present study was undertaken to investigate the potential of ethyl acetate fraction obtained from the fruits of Xylocarpus moluccensis alcoholic extract (CDR-267-F018) against cardiac hypertrophy in rats. Experimental Procedure: Cardiac hypertrophy was achieved in Wistar rats through isoproterenol and treated either with propranolol or CDR-267-F018 for 14 days. Results and Conclusion: CDR-267-F018 treatment reduced isoproterenol induced cardiac hypertrophy as assessed by 2D-echocardiography and supported by reduction in ANP, BNP, β-MHC, NPP-A and increased expression of vascular endothelial growth factor receptor 1. CDR-267-F018 treatment tightly regulated inflammation by controlling the plasma proinflammatory cytokines tumor necrosis factor-α and IFN-γ, plasma EMP level and NF-κB, Akt and ERK. Further, CDR-267-F018 treatment reduced fibrosis by regulating Col18a1, FGF-21 and MMP2. In total, CDR-267-F018 protected rat heart against isoproterenol induced cardiac hypertrophy by acting on inflammation, fibrosis and by improving angiogenesis.


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