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ORIGINAL ARTICLE
Year : 2021  |  Volume : 17  |  Issue : 73  |  Page : 23-30

Vasorelaxant and antioxidant activity of some medicinal plants from Campeche, Mexico


1 Faculty of Chemical Biological Sciences, Autonomous University of Campeche, Campeche, Mexico
2 Department of Environmental Microbiology and Biotechnology, Autonomous University of Campeche, Campeche, Mexico
3 Historical and Social Research Center, Autonomous University of Campeche, Campeche, Mexico
4 Department of Marine Resources, Center for Research and Advanced Studies Merida, Yucatan; National Council for Science and Technology, Morelos, Mexico
5 Pharmacy Faculty, Autonomous University of Morelos State, Cuernavaca, Morelos, Mexico

Correspondence Address:
Francisco Javier Aguirre Crespo
Av. Agustín Melgar S/N entre Calle 20 y Juan de la Barrera, Col. Buenavista, CP 24039, San Francisco de Campeche, Campeche
Mexico
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_291_20

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Context: Brosimum alicastrum, Cnidoscolus chayamansa, Tradescantia spathacea, Turnera diffusa, Manilkara zapota, and Jatropha gaumeri are medicinal plants recognized in Mexican Mayan Culture. Aim: Methanol leaves extracts of these plants were use as raw material to develop a phytochemical, spectroscopy, and pharmacological analysis. Subjects and Methods: Methanol maceration was carried out and were compared in terms of yield extraction, chlorophyll, simple phenolic and flavonoids content, antioxidant activity (DPPH and β-Carotene bleaching models), as well as isolated aorta rings (E+), precontracted with noradrenaline. Results: Best content of simple phenolic and flavonoids compounds was recorder in B. alicastrum, J. gaumeri and T. diffusa. J. gaumeri extract exert an antioxidant (β-carotene bleaching: EC50: 0.8 ± 0.1 μg/mL, Emax: 85.7% ± 0.4%; DPPH: EC50: 60.3 ± 1.8 μg/mL, Emax: 60.4% ± 1.8%; P < 0.05) and vasorelaxant (EC50: 161.61 ± 7.45 μg/mL; Emax: 79.71% ± 3.88%; P < 0.05) activity in a concentration dependent-manner. Fourier transform infrared spectroscopy analysis allowed estimating a 1.26 and 2.28% of quercetin (Q) and gallic acid (GA) in J. gaumeri. GA exerts antioxidant activity in DPPH model (EC50: 1.6 ± 0.2 μg/mL; Emax: 92.9% ± 3.3%) and Q/GA (1:2) mixture improves inhibition of β-carotene bleaching (EC50: 0.005 ± 0.005 μg/mL; Emax: 69.2% ± 0.7%; P < 0.05). Conclusion: J. gaumeri is a medicinal plant employed in Mayan traditional medicine and GA and Q could be related to traditional uses, as well as responsible for the pharmacological effects. GA and Q interactions improve inhibition β-Carotene bleaching activity, which suggests greater solubility in lipophilic systems and potential interactions at the plasma membrane level.


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