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Year : 2018  |  Volume : 14  |  Issue : 58  |  Page : 528-533

Antioxidant effect of royal jelly on immune status of hyperglycemic rats

1 Department of Anatomy, Faculty of Medicine, Umm Al Qura University, Makkah, KSA
2 Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, KSA; Department of Nutrition and Food Science, Faculty of Home Economics, Menofia University, Egypt
3 Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, KSA; Department of Anatomy and Embryology, Faculty of Medicine Zagazig University, Egypt
4 Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, KSA

Correspondence Address:
Abdullah G Al-Kushi
Department of Anatomy, Faculty of Medicine, Umm Al-Qura University, Azeezeeyah, Makkah 21955, PO Box 57039
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_87_18

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Context: Diabetes mellitus and its increasing effect on endocrine functionality have been widely observed. Aims: The present study aims at investigating the histopathological changes of splenic cells in diabetic rats. Subjects and Methods: The experiment was conducted on adult male albino rats. They were categorized into four groups: Group I (negative control; fed with standard basal diet [SBD]), Group II (positive control; fed with SBD), Group III (fed on SBD + dose of 50 mg/kg of body weight royal jelly [RJ]) and Group IV were given orally RJ 100 mg/kg of b.wt. The food intake ratio and body weight gain were monitored on a weekly basis. The blood sample and organ tissue samples were collected at the end of feeding and biochemical and immunological analysis was performed for determining the blood glucose level and immune status of the investigated rats. Superoxide dismutase activity was also determined. Results: The results showed increased antioxidant enzymes and lowered glucose levels in diabetic rats fed with RJ. Conclusion: Histopathology tissues indicated moderate to extreme cellular transformations upon treated rats. The histopathological variations in treated rat cells were found to be evident. For this reason, there is likelihood that RJ may have an effect on splenic tissue repair in diabetic rats. Abbreviations used: RJ: Royal jelly; SBD: Standard basal diet; SPSS: Statistical package for the social science; STZ: Streptozotocin; BWG: Body weight gain; SD: Standard deviation.

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