| ORIGINAL ARTICLE |
|
| Year : 2016 | Volume
: 12
| Issue : 45 | Page : 57-63 |
|
|
Influence of chitosan nanoparticles as the absorption enhancers on salvianolic acid B In vitro and In vivo evaluation
Xin Jin1, Shi-bing Zhang1, Shi-meng Li1, Ke Liang2, Zeng-yong Jia1
1 Department of Pharmacy, The Suqian First Hospital, Suqian, Jiangsu 223800, China
2 Depratment of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
Correspondence Address:
Ke Liang
The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006
China
Zeng-yong Jia
The Suqian First Hospital, 120 Suzhi Road, Suqian, Jiangsu, 223800
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1296.176047
|
|
|
Background: Salvianolic acid B (SalB) represents the most abundant and bio-active phenolic constituent among the water-soluble compounds of Salvia miltiorrhiza. But the therapeutic potential of SalB has been significantly restricted by its poor absorption. Methods: In this study, chitosans (CS) and CS nanoparticles (NPs) with different molecular weights (MWs), which have influence on the absorption of SalB, was also investigated. Results: As a preliminary study, water-soluble CS with various MWs (3, 30, 50, and 100 kDa) was chosen. We investigated the MW-dependent Caco-2 cell layer transport phenomena in vitro of CS and NPs at concentrations (4 μg/ml, w/v). SalB, in presence CS or NPs has no significant toxic effect on Caco-2 cell. As the MW increases, the absorption enhancing effect of CS increases. However, as the MW decreases, the absorption enhancing effect of NPs increases. The AUC 0-∞ of the SalB-100 kDa CS was 4.25 times greater than that of free SalB. And the AUC 0-∞ of the SalB-3 kDa NPs was 16.03 times greater than that of free SalB. Conclusion: CS and NPs with different MWs as the absorption enhancers can promote the absorption of SalB. And the effect on NPs is better than CS. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
